, Volume 26, Issue 1, pp 145-146
Date: 30 Aug 2010

Atypical hemolytic uremic syndrome associated with H1N1 influenza A virus infection

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Atypical nonfamilial HUS can be caused by infections, medications, systemic diseases, malignancy, and pregnancy [1]. Infection with influenza A or Epstein Barr virus has been rarely associated with atypical HUS. The 2009 pandemic of influenza A due to a novel swine-origin influenza A:H1N1 strain in the spring of 2009 has been characterized by widespread illness in young children and an increase in the number of fatal cases in the pediatric age group [2]. We report the first case of atypical HUS associated with confirmed pandemic influenza A:H1N1 infection and describe the clinical course of this illness.

A 5-year-old girl had a history of reactive airway disease and hospitalization for pneumonia 1 year prior to presentation. Her immunizations were up to date, and she had received the seasonal influenza but not the 2009 pandemic influenza A:H1N1 vaccine. Three days prior to admission, she presented with 3 days of fever (103°F), frontal headaches, sinus pain, cough, abdominal pain, a ...