Pediatric Nephrology

, Volume 25, Issue 9, pp 1747–1750

Beneficial effect of cinacalcet in a child with familial hypocalciuric hypercalcemia

Brief Report

DOI: 10.1007/s00467-010-1547-5

Cite this article as:
Alon, U.S. & VanDeVoorde, R.G. Pediatr Nephrol (2010) 25: 1747. doi:10.1007/s00467-010-1547-5

Abstract

We describe a child with familial hypocalciuric hypercalcemia (FHH) in whom the hypercalcemia seemed to interfere with tissue healing after tympanoplasty. Consequently, he was placed on cinacalcet (30 mg/day), changed after 2 weeks to 60 mg/day. The treatment resulted in a decrease in serum parathyroid hormone (PTH) from 148 to 32 pg/mL (normal 7–75) and ionized calcium from 1.48 to 1.23 mmol/L (1.13–1.34), as well as successful healing of the revised surgical scar. Over the 12-month treatment period no complications were noted. We conclude that cinacalcet may be considered a new, and currently the only, tool in treating children with symptomatic FHH.

Keywords

Hypercalcemia Familial hypocalciuric hypercalcemia Calcimimetics Calcium sensing receptor Parathyroid hormone 

Copyright information

© IPNA 2010

Authors and Affiliations

  1. 1.Section of Pediatric Nephrology, Bone and Mineral Disorders Clinic, Children’s Mercy Hospitals and ClinicsUniversity of Missouri at Kansas CityKansas CityUSA