Pediatric Nephrology

, Volume 25, Issue 6, pp 1081–1089

Bone metabolism in oxalosis: a single-center study using new imaging techniques and biomarkers

  • Justine Bacchetta
  • Sonia Fargue
  • Stéphanie Boutroy
  • Odile Basmaison
  • Nicolas Vilayphiou
  • Ingrid Plotton
  • Fitsum Guebre-Egziabher
  • Bruno Dohin
  • Rémi Kohler
  • Pierre Cochat
Original Article

DOI: 10.1007/s00467-010-1453-x

Cite this article as:
Bacchetta, J., Fargue, S., Boutroy, S. et al. Pediatr Nephrol (2010) 25: 1081. doi:10.1007/s00467-010-1453-x

Abstract

The deposition of calcium oxalate crystals in the kidney and bone is a hallmark of primary hyperoxaluria type 1 (PH1). We report here an evaluation of the bone status of 12 PH1 children based on bone biomarkers [parathyroid hormone, vitamin D, fibroblast growth factor 23 (FGF23)] and radiological assessments (skeletal age, three-dimensional high-resolution peripheral quantitative computed tomography, HR-pQCT) carried out within the framework of a cross-sectional single-center study. The controls consisted of healthy and children with chronic kidney disease already enrolled in local bone and mineral metabolism studies. The mean age (±standard deviation) age of the patients was 99 (±63) months. Six children suffered from fracture. Bone maturation was accelerated in five patients, four of whom were <5 years. The combination of new imaging techniques and biomarkers highlighted new and unexplained features of PH1: advanced skeletal age in young PH1 patients, increased FGF23 levels and decreased total volumetric bone mineral density with bone microarchitecture alteration.

Keywords

Bone imagingChildrenFGF23Primary hyperoxaluriaSkeletal age

Copyright information

© IPNA 2010

Authors and Affiliations

  • Justine Bacchetta
    • 1
    • 2
    • 3
    • 4
  • Sonia Fargue
    • 1
    • 3
    • 4
  • Stéphanie Boutroy
    • 2
    • 3
  • Odile Basmaison
    • 1
    • 4
  • Nicolas Vilayphiou
    • 2
    • 3
  • Ingrid Plotton
    • 3
    • 4
    • 5
  • Fitsum Guebre-Egziabher
    • 3
    • 4
    • 6
  • Bruno Dohin
    • 7
    • 8
  • Rémi Kohler
    • 3
    • 4
    • 7
  • Pierre Cochat
    • 1
    • 3
    • 4
  1. 1.Service de Néphrologie et Rhumatologie Pédiatriques, Centre de Référence des Maladies Rénales RaresHôpital Femme Mère EnfantBronFrance
  2. 2.INSERM U831LyonFrance
  3. 3.Université de LyonLyonFrance
  4. 4.Centre Hospitalier Universitaire (CHU) de LyonHospices Civils de LyonLyonFrance
  5. 5.Service d’Endocrinologie Moléculaire et Maladies Rares, Centre de Biologie EstHospices Civils de LyonLyonFrance
  6. 6.Département de NéphrologieHôpital Edouard HerriotLyonFrance
  7. 7.Service de Chirurgie Orthopédique PédiatriqueHôpital Femme Mère EnfantLyonFrance
  8. 8.Université Jean MonnetSaint EtienneFrance