Pediatric Nephrology

, Volume 25, Issue 9, pp 1597–1606

Vitamin D insufficiency: implications for the immune system

  • Femke Baeke
  • Conny Gysemans
  • Hannelie Korf
  • Chantal Mathieu
Review

DOI: 10.1007/s00467-010-1452-y

Cite this article as:
Baeke, F., Gysemans, C., Korf, H. et al. Pediatr Nephrol (2010) 25: 1597. doi:10.1007/s00467-010-1452-y

Abstract

Chronic kidney disease (CKD) is characterized by a loss of kidney function and dysregulation of vitamin D metabolism. Well known are the defects in final activation of vitamin D to 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], resulting in renal osteodystrophy. However, in recent years, 1,25(OH)2D3 has been identified as having effects far beyond calcium and bone metabolism. In this review, specific attention is given to the effects of 1,25(OH)2D3 on the immune system and the implications of vitamin D deficiency, a feature of many patients with CKD, on immune function.

Keywords

Vitamin DImmune modulationChronic kidney disease

Copyright information

© IPNA 2010

Authors and Affiliations

  • Femke Baeke
    • 1
  • Conny Gysemans
    • 1
  • Hannelie Korf
    • 1
  • Chantal Mathieu
    • 1
  1. 1.Laboratory of Experimental Medicine and Endocrinology (LEGENDO)Katholieke Universiteit Leuven (KUL)LeuvenBelgium