Pediatric Nephrology

, Volume 24, Issue 9, pp 1753–1755

Fatal pulmonary fibrosis after rituximab administration

  • Marie-Camille Chaumais
  • Arnaud Garnier
  • François Chalard
  • Michel Peuchmaur
  • Stephane Dauger
  • Evelyne Jacqz-Agrain
  • Georges Deschênes
Brief Report

DOI: 10.1007/s00467-009-1195-9

Cite this article as:
Chaumais, MC., Garnier, A., Chalard, F. et al. Pediatr Nephrol (2009) 24: 1753. doi:10.1007/s00467-009-1195-9

Abstract

Idiopathic nephrotic syndrome is the most frequent glomerular disease during childhood. Although immunosuppressive agents are usually effective, some severe cases remain difficult to treat. We describe a female patient with secondary steroid-resistant nephrotic syndrome who no longer responded to conventional treatment. Owing to cyclosporine toxicity, rituximab was administered. Three days after treatment the patient’s clinical condition dramatically worsened and she developed acute respiratory distress. Despite all means used to treat her, she died 5 weeks after rituximab infusion. A pulmonary biopsy showed extensive fibrosis, while the alveolar epithelium was no longer visible.

Keywords

Nephrotic syndromePrednisoneCyclosporineChildrenVirus

Copyright information

© IPNA 2009

Authors and Affiliations

  • Marie-Camille Chaumais
    • 1
  • Arnaud Garnier
    • 2
  • François Chalard
    • 3
  • Michel Peuchmaur
    • 4
  • Stephane Dauger
    • 5
  • Evelyne Jacqz-Agrain
    • 1
  • Georges Deschênes
    • 2
  1. 1.Department of Pediatric Pharmacology and PharmacogeneticsRobert Debré HospitalParisFrance
  2. 2.Department of Pediatric NephrologyRobert Debré HospitalParis Cedex 19France
  3. 3.Department of ImageryRobert Debré HospitalParisFrance
  4. 4.Department of AnatomopathologyRobert Debré HospitalParisFrance
  5. 5.Department of Pediatric Intensive CareRobert Debré HospitalParisFrance