Original Article

Pediatric Nephrology

, Volume 24, Issue 8, pp 1561-1568

First online:

Quality of life of adolescents with end-stage renal disease and kidney transplant

  • Isolina Riaño-GalánAffiliated withDivision of Paediatrics, Hospital San Agustín
  • , Serafín MálagaAffiliated withDivision of Paediatric Nephrology, Hospital Universitario Central de Asturias Email author 
  • , Luis RajmilAffiliated withAgència d’Avaluació de Tecnologia i Recerca Mèdiques (AATRM), Institut Municipal d’Investigació Mèdica (IMIM) and CIBER en Epidemiología y Salud Pública (CIBERESP)
  • , Gema AricetaAffiliated withDivision of Paediatric Nephrology, Hospital Clínico de Santiago
  • , Mercedes NavarroAffiliated withDivision of Paediatric Nephrology, Hospital Universitario Infantil La Paz
  • , Cesar LorisAffiliated withDivision of Paediatric Nephrology, Hospital Miguel Servet
  • , Alfredo ValloAffiliated withDivision of Paediatric Nephrology, Hospital Cruces

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Abstract

The health-related quality of life (HRQOL) of adolescents with end-stage renal disease (ESRD) is an important marker of disease burden. Our aims were to investigate HRQOL in a group of children and adolescents with ESRD and to compare them with the reference population norms. Ours was a cross-sectional study of 81 patients aged 10 years to 21 years with ESRD (68 with kidney transplants and 13 on dialysis) at five Spanish paediatric nephrology centres. HRQOL was investigated with the Spanish version of the child health and illness profile, adolescent edition (CHIP-AE). Clinical variables such as underlying diagnosis, number of rejection episodes, pre-emptive transplantation, anaemia and height were also analysed. No differences were found between patients with kidney transplants and their healthy peers in any domain or sub-domain of CHIP-AE. The group on dialysis scored lower than healthy controls and patients with transplants for satisfaction with health. Discomfort was higher in patients with transplants who had suffered one rejection episode. Physical discomfort was increased in anaemic patients with transplants. Short patients scored less in the satisfaction domain, with lower self-esteem and lower satisfaction with health. Adolescents with kidney transplants had better satisfaction with health than the group on dialysis, which matched the level of a healthy population. Further long-term prospective research is warranted.

Keywords

Dialysis End-stage renal disease Health-related quality of life Kidney transplant Paediatric Teenagers