Pediatric Nephrology

, Volume 24, Issue 8, pp 1533–1538

Urinary proteins in children with urinary tract infection

  • Lena Andersson
  • Iulian Preda
  • Mirjana Hahn-Zoric
  • Lars Å. Hanson
  • Ulf Jodal
  • Rune Sixt
  • Lars Barregard
  • Sverker Hansson
Original Article

DOI: 10.1007/s00467-009-1173-2

Cite this article as:
Andersson, L., Preda, I., Hahn-Zoric, M. et al. Pediatr Nephrol (2009) 24: 1533. doi:10.1007/s00467-009-1173-2

Abstract

The aim of this study was to test our hypothesis that the urinary excretion of C-reactive protein (CRP), alpha 1-microglobulin (A1M), retinol-binding protein (RBP) and Clara cell protein (CC16) is increased in children with urinary tract infection (UTI) and relates to renal damage as measured by acute dimercaptosuccinic acid (DMSA) scintigraphy. Fifty-two children <2 years of age with UTI were enrolled in the study, 44 of whom were febrile. The control group consisted of 23 patients with non-UTI infection and elevated serum CRP (s-CRP) levels. Thirty-six patients had abnormal DMSA uptake, classified as mild, moderate or severe damage (DMSA class 1, 2, 3, respectively). There was a significant association between DMSA class and the excretion of urinary RBP (u-RBP) and u-CC16. There was also a significant difference in u-CRP levels between children with UTI and control children with non-UTI infections, although u-CRP excretion was not significantly correlated to DMSA class. In conclusion, the urinary excretion of the low-molecular-weight proteins RBP and CC16 showed a strong association with uptake defects on renal DMSA scans. The urinary level of CRP seems to distinguish between children with UTI and other febrile conditions. A combination of these biomarkers may be useful in the clinical assessment of children with UTI.

Keywords

Alpha 1-microglobulin Biomarker Clara cell protein C-reactive protein Scintigraphy Retinol-binding protein 

Copyright information

© IPNA 2009

Authors and Affiliations

  • Lena Andersson
    • 1
  • Iulian Preda
    • 2
  • Mirjana Hahn-Zoric
    • 3
  • Lars Å. Hanson
    • 3
  • Ulf Jodal
    • 2
  • Rune Sixt
    • 2
  • Lars Barregard
    • 1
  • Sverker Hansson
    • 2
  1. 1.Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and AcademyUniversity of GothenburgGothenburgSweden
  2. 2.Pediatric Uro-Nephrologic Centre, Queen Silvia Children’s HospitalUniversity of GothenburgGothenburgSweden
  3. 3.Department of Clinical Immunology, Sahlgrenska University Hospital and AcademyUniversity of GothenburgGothenburgSweden

Personalised recommendations