Pediatric Nephrology

, Volume 24, Issue 7, pp 1277–1285

Insulin-like growth factor-I and bone: lessons from mice and men

Review

DOI: 10.1007/s00467-008-1040-6

Cite this article as:
Kawai, M. & Rosen, C.J. Pediatr Nephrol (2009) 24: 1277. doi:10.1007/s00467-008-1040-6

Abstract

Studies of humans and animals have illustrated a strong association between insulin-like growth factor (IGF)-I and skeletal acquisition. However, the precise molecular and cellular mechanisms underlying this effect still largely remain unknown. Recent advances in molecular and genetic techniques for in vivo studies provide excellent tools for us to explore how circulating and skeletal insulin-like growth factor-I (IGF-I) may affect not only peak bone mass but also bone loss. This review highlights recent findings that shed new light on the interaction of the IGF-I signaling pathway with other skeletal networks, and the role of IGF-I in the bone marrow milieu.

Keywords

Insulin-like growth factor-I Skeletal acquisition 

Copyright information

© IPNA 2008

Authors and Affiliations

  1. 1.Maine Medical Center Research InstituteScarboroughUSA

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