, Volume 25, Issue 1, pp 61-74,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 24 Oct 2008

Mechanism of cellular rejection in transplantation

Abstract

The explosion of new discoveries in the field of immunology has provided new insights into mechanisms that promote an immune response directed against a transplanted organ. Central to the allograft response are T lymphocytes. This review summarizes the current literature on allorecognition, costimulation, memory T cells, T cell migration, and their role in both acute and chronic graft destruction. An in depth understanding of the cellular mechanisms that result in both acute and chronic allograft rejection will provide new strategies and targeted therapeutics capable of inducing long-lasting, allograft-specific tolerance.