Pediatric Nephrology

, Volume 24, Issue 3, pp 613–617

Reversal of hypercalcemic acute kidney injury by treatment with intravenous bisphosphonates

  • Ari Auron
  • Leyat Tal
  • Tarak Srivastava
  • Uri S. Alon
Brief Report

DOI: 10.1007/s00467-008-1011-y

Cite this article as:
Auron, A., Tal, L., Srivastava, T. et al. Pediatr Nephrol (2009) 24: 613. doi:10.1007/s00467-008-1011-y

Abstract

We present the details of three children with hypercalcemia-induced acute kidney injury (AKI). After traditional therapy with fluids, loop diuretics, steroids and calcitonin had failed to correct the hypercalcemia, they were given treatment with low doses of intravenous (i.v.) pamidronate, which resulted in normalization of serum calcium and kidney function. In one child Doppler renal ultrasound revealed dampened arterial blood flow, which resolved with normalization of serum calcium. On the basis of cumulative data and our experience, we suggest that i.v. application of bisphosphonates be moved from the second to the first line of treatment of hypercalcemic AKI.

Keywords

Acute kidney injuryHypercalcemiaRenal arteryBisphosphonates

Copyright information

© IPNA 2008

Authors and Affiliations

  • Ari Auron
    • 1
  • Leyat Tal
    • 2
  • Tarak Srivastava
    • 2
  • Uri S. Alon
    • 2
  1. 1.Section of Pediatric NephrologyBlank Children’s Hospital, Iowa Health SystemDes MoinesUSA
  2. 2.Bone and Mineral Disorders Clinic, Section of Pediatric Nephrology, Children’s Mercy Hospital and ClinicsUniversity of Missouri–Kansas City School of MedicineKansas CityUSA