Pediatric Nephrology

, Volume 24, Issue 1, pp 83–89

Evaluation of antibody response to the heptavalent pneumococcal conjugate vaccine in pediatric chronic kidney disease

  • Simone Vieira
  • Evandro Roberto Baldacci
  • Magda Carneiro-Sampaio
  • Ulysses Doria Filho
  • Vera Hermina Koch
Original Article

DOI: 10.1007/s00467-008-0989-5

Cite this article as:
Vieira, S., Baldacci, E.R., Carneiro-Sampaio, M. et al. Pediatr Nephrol (2009) 24: 83. doi:10.1007/s00467-008-0989-5

Abstract

Pneumococcal vaccination has been recommended for immunocompromised children, including patients with chronic kidney disease. We determined pneumococcal immunoglobulin (Ig)G antibodies to serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F before and after 48 pediatric patients with chronic renal failure were administered heptavalent conjugated pneumococcal vaccine. The patients were between 1 and 9 years of age and were separated into a conservative treatment group (Group 1) and a dialysis group (Group 2). The antibody response to the vaccinal serotypes was evaluated by measuring antibody concentrations before the first dose and 60 days after the second one. Pre-vaccinal IgG concentrations ≥0.35 μg/ml were detected for all serotypes in at least 50% of the patients in both groups. Patients from both groups showed a statistically indistinguishable behavior in terms of the medians of post-vaccination IgG levels. An “adequate” vaccine response was defined as a post-immunization level of specific pneumococcal serotype antibody ≥0.35 μg/ml, based on the World Health Organization’s (WHO) protective antibody concentration definition for pneumococcal conjugate vaccines, or on a fourfold increase over baseline for at least five of the seven antigens of the vaccine. An “adequate” vaccinal response was obtained in 100% of the patients of both groups using WHO’s definition, or in 45.8% of Group 1 patients and 37.5% of Group 2 patients when the criterion was a fourfold antibody increase over baseline antibody concentrations.

Keywords

ChildChronic kidney diseasePneumococcal conjugate vaccineStreptococcus pneumoniaeVaccinal response

Copyright information

© IPNA 2008

Authors and Affiliations

  • Simone Vieira
    • 1
  • Evandro Roberto Baldacci
    • 2
  • Magda Carneiro-Sampaio
    • 3
  • Ulysses Doria Filho
    • 4
  • Vera Hermina Koch
    • 5
    • 6
  1. 1.Pediatric Nephrology UnitInstituto da Criança do Hospital das Clinicas da Faculdade de Medicina, Universidade de São PauloSão PauloBrazil
  2. 2.Pediatric Infectious Diseases UnitInstituto da Criança do Hospital das Clinicas da Faculdade de Medicina, Universidade de São PauloSão PauloBrazil
  3. 3.Laboratório de Imunologia, Instituto de Ciências BiomédicasUniversidade de São PauloSão PauloBrazil
  4. 4.Biostatistics UnitInstituto da Criança do Hospital das Clinicas da Faculdade de Medicina, Universidade de São PauloSão PauloBrazil
  5. 5.Pediatric Nephrology UnitInstituto da Criança do Hospital das Clínicas da Faculdade de Medicina, Universidade de São PauloSão PauloBrazil
  6. 6.São PauloBrazil