Brief Report

Pediatric Nephrology

, 22:1373

First online:

Nephrotic syndrome preceding psoriasis in children

  • Arvind BaggaAffiliated withDivision of Nephrology, Department of Paediatrics, All India Institute of Medical Sciences Email author 
  • , Shina MenonAffiliated withDivision of Paediatric Nephrology, All India Institute of Medical Sciences
  • , Pankaj HariAffiliated withDivision of Paediatric Nephrology, All India Institute of Medical Sciences
  • , Mukta MantanAffiliated withDivision of Paediatric Nephrology, All India Institute of Medical Sciences
  • , Amit DindaAffiliated withDepartment of Pathology, All India Institute of Medical Sciences

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Abstract

Nephrotic syndrome is considered to be a late complication of psoriasis, reported usually in adults and characterized by IgA nephropathy or focal segmental glomerulosclerosis. We report on four children in whom steroid-resistant nephrotic syndrome either preceded (n = 3), by 41–120 months, or occurred simultaneously (n = 1) with psoriasis; renal histology showed minimal change disease. Therapy with corticosteroids and cyclosporine resulted in remission of renal and cutaneous symptoms. Minimal change nephrotic syndrome and psoriasis might share similar mechanisms of pathogenesis involving cell-mediated immunity.

Keywords

Cyclosporine Minimal change disease Psoriasis T lymphocytes