Pediatric Nephrology

, 22:1373

Nephrotic syndrome preceding psoriasis in children

Authors

    • Division of Nephrology, Department of PaediatricsAll India Institute of Medical Sciences
  • Shina Menon
    • Division of Paediatric NephrologyAll India Institute of Medical Sciences
  • Pankaj Hari
    • Division of Paediatric NephrologyAll India Institute of Medical Sciences
  • Mukta Mantan
    • Division of Paediatric NephrologyAll India Institute of Medical Sciences
  • Amit Dinda
    • Department of PathologyAll India Institute of Medical Sciences
Brief Report

DOI: 10.1007/s00467-007-0487-1

Cite this article as:
Bagga, A., Menon, S., Hari, P. et al. Pediatr Nephrol (2007) 22: 1373. doi:10.1007/s00467-007-0487-1

Abstract

Nephrotic syndrome is considered to be a late complication of psoriasis, reported usually in adults and characterized by IgA nephropathy or focal segmental glomerulosclerosis. We report on four children in whom steroid-resistant nephrotic syndrome either preceded (n = 3), by 41–120 months, or occurred simultaneously (n = 1) with psoriasis; renal histology showed minimal change disease. Therapy with corticosteroids and cyclosporine resulted in remission of renal and cutaneous symptoms. Minimal change nephrotic syndrome and psoriasis might share similar mechanisms of pathogenesis involving cell-mediated immunity.

Keywords

CyclosporineMinimal change diseasePsoriasisT lymphocytes

Copyright information

© IPNA 2007