Abstract
To investigate the association between HLA-DRB1* alleles and post-streptococcal acute glomerulonephritis (PSAGN) in Egyptian children, 32 unrelated patients with PSAGN and 380 healthy individuals from the same locality were typed for DRB1* alleles using the polymerase chain-reverse hybridization technique. Patients with PSAGN had significantly increased frequency of both DRB1* 03011 (46.9 vs. 19.2% in controls, P = 0.00025) and DRB1* 1105 (31.1 vs. 15.6% in controls, P = 0.0097) alleles. However, after correction of P values, only the difference for DRB1* 03011 allele remained significant (Pc = 0.025). Their relative risks were significantly high (3.71, confidence interval [CI] = 1.8–7.8, and 3.57, CI = 1.4–8.9 respectively). No significant differences in the frequency of the two alleles were observed among patients with different grades of hypertension or proteinuria. In conclusion, DRB1* 03011, and possibly 1105, alleles confer susceptibility to PSAGN. However, the severity of the disease is not determined by these two alleles.
Similar content being viewed by others
References
Glassock RJ, Brenner CM (1973) In: Brenner BM (ed) The kidney. Saunders, Philadelphia, p 961
Braun DG, Schalch W, Schmid I (1980) In: Read SE, Zabriskie JB (eds) Streptococcal diseases and the immune response. Academic, New York, p 317
Read SE, Reid H, Poon King T, Fischetti VA, Zabriskie JB, Rapaport FT (1977) HLA and predisposition to the non-suppurative sequelae of group A streptococcal infections. Transplant Proc 9:543–546
Layrisse Z, Rodriguez-Itrube B, Garcia-Ramirez R, Rodriguez A, Tiwari J (1983) Family studies of the HLA system in acute post streptococcal glomerulonephritis. Hum Immunol 7:177–185
Sasazuki T, Hayase R, Iwamoto I, Tsuchida H (1979) HLA and acute streptococcal glomerulonephritis. N Engl J Med 301:1184–1185
Unanue ER, Allen PM (1987) The basis for the immunoregulatory role and other accessory cells. Science 235:551–557
Marsh SG (1997) Nomenclature for factors of HLA system, update January/February. WHO Nomenclature Committee for Factors of HLA System. Hum Immunol 53:224
Bodmer WF (1997) HLA: what’s the name? A commentary on HLA nomenclature development over the years. Tissue Antigens 49:293–296
National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114(2 Suppl 4th report):555–576
Buyse I, Decorte R, Baens M, Cuppens H, Semana G, Emonds MP, Marynen P, Cassiman JJ (1993) Rapid DNA typing of class II HLA antigens using the polymerase chain reaction and reverse dot blot hybridization. Tissue Antigens 41:1–14
Thonnard J, Deldime F, Heusterspreute M, Delepaut B, Hanon F, De Bruyere M, Philippe M (1995) HLA class II genotyping: two assay systems compared. Clin Chem 41:553–556
Vaughan RW (1991) PCR-SSO typing for HLA-DRB alleles. Eur J Immunogen 18:69–80
Emery AEH (1976) In: Emery AEH (ed) Methodology in medical genetics, 1st edn. Churchill Livingstone, Edinburgh, p 98
Bengtsson B, Thomson G (1981) Measuring the strength of association between HLA antigens and diseases. Tissue Antigens 18:356–363
Well WC (1812) Observation on dropsy which succeeds scarlet fever. Trans Soc Improve Med Chir Know 13:167–168
Sasazuki T, Nishimura Y, Muto M, Ohta N (1983) Linked genes controlling the immune response and disease susceptibility. Immunol Rev 70:51–75
Tomai M, Kotb M, Majumdar G, Beachey EH (1990) Superantigenicity of streptococcal M protein. J Exp Med 172:359–362
Abe J, Forrester J, Nakahara T, Lafferty JA, Kotzin BL, Leung DY (1991) Selective stimulation of human T cells with streptococcal erythrogenic toxins A and B. J Immunol 146:3747–3750
Kotzin BL, Leung DY, Kappler J, Marrack P (1993) Superantigens and their potential role in human disease. Adv Immunol 54:99–166
Yoshizawa N, Treser G, McClung JA, Sagel I, Takahashi K (1983) Circulating immune complexes in patients with uncomplicated group A streptococcal pharyngitis and patients with acute post-streptococcal glomerulonephritis. Am J Nephrol 3:23–29
Tomlinson IP, Bodmer WF (1995) The HLA system and the analysis of multifactorial disease. Trends Genet 11:493–498
Imanishi T, Akaza T, Kimura A, Tokunaga K, Gojobori T (1992) Allele frequencies and haplotype frequencies for HLA and complement loci in various ethnic groups. In: Tsji K, Aizawa M, Sasazuki T (eds) HLA 1991. Oxford University Press, Oxford, pp 1065–220
Mori K, Sasazuki T, Kimura A, Ito YP (1996) HLA-DP antigens and post-streptococcal acute glomerulonephritis. Acta Pediatr 85:916–918
Kotb M, Norrby-Teglund A, McGeer A, El-Sherbini H, Dorak MT, Khurshid A, Green K, Peeples J, Wade J, Thomson G, Schwartz B, Low DE (2002) An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med 8:1398–1404
Rees AG (1997) Immunogenetics of renal disease. In: Neilson EG, Couser WG (eds) Immunologic renal disease. Lippincott-Raven, Philadelphia, pp 99–120
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bakr, A., Mahmoud, L.AN., Al-Chenawi, F. et al. HLA-DRB1* alleles in Egyptian children with post-streptococcal acute glomerulonephritis. Pediatr Nephrol 22, 376–379 (2007). https://doi.org/10.1007/s00467-006-0324-y
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00467-006-0324-y