Is there a role for vincristine in nephrotic syndrome?
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The recent report by Kausman et al. on the effect of vincristine on 12 children with steroid-dependent nephrotic syndrome  is the third retrospective publication on this subject in Pediatric Nephrology [2, 3] and brings the number of children reported to 27. As in the previous reports, Kausman’s patients had already been treated with steroids and cyclophosphamide; ten had also received cyclosporin. One of Kausman’s patients achieved long-term remission, bringing the total reported to 5/27. They also record an increase in the mean duration of remissions from 3 months to 8 months.
We can add a further 17 patients to this group. Nine had steroid resistance, of whom eight had focal segmental glomerulosclerosis (FSGS), and eight had steroid dependence, of whom three had FSGS, the remainder having minimal lesion. The median (range) age was 5.3 (1.2 to 14.4) years, and 11 were boys. All 17 had received previous treatment with steroids, 12/17 with cyclophosphamide, and 4/17 with levamis ...
- Kausman JY, Lei Y, Jones CL, Johnstone L, Powell HR (2005) Vincristine in steroid dependent nephrotic syndrome. Pediatr Nephrol 20:1416–1419 CrossRef
- Almeida MP, Almeida HA, Rosa FC (1994) Vincristine in steroid resistant nephrotic syndrome. Pediatr Nephrol 8:79–80 CrossRef
- Goonasekera CD, Koziell AB, Hulton SA, Dillon MJ (1998) Vincristine and focal segmental glomerulosclerosis: do we need a multicentre trial? Pediatr Nephrol 12:284–289 CrossRef
- Is there a role for vincristine in nephrotic syndrome?
Volume 21, Issue 4 , p 597
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