The clinical trial imperative
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- Gipson, D. & Trachtman, H. Pediatr Nephrol (2005) 20: 5. doi:10.1007/s00467-004-1681-z
As clinical judgment has joined forces with evidence-based medicine, nephrologists critically assess the validity of the data available to support therapeutic decisions for children with kidney disease. Unfortunately, a paucity of data often prevents the practice of evidence-based medicine. Three scenarios illustrating the status of evidence and clinical decision making are provided. A review of the pediatric nephrology literature supports a call for general support of ongoing clinical trials and encourages the creation of additional feasible clinical trials to improve the practice of medicine.