Pediatric Nephrology

, Volume 20, Issue 1, pp 5–9

The clinical trial imperative

Editorial Commentary

DOI: 10.1007/s00467-004-1681-z

Cite this article as:
Gipson, D. & Trachtman, H. Pediatr Nephrol (2005) 20: 5. doi:10.1007/s00467-004-1681-z


As clinical judgment has joined forces with evidence-based medicine, nephrologists critically assess the validity of the data available to support therapeutic decisions for children with kidney disease. Unfortunately, a paucity of data often prevents the practice of evidence-based medicine. Three scenarios illustrating the status of evidence and clinical decision making are provided. A review of the pediatric nephrology literature supports a call for general support of ongoing clinical trials and encourages the creation of additional feasible clinical trials to improve the practice of medicine.



Copyright information

© IPNA 2004

Authors and Affiliations

  1. 1.Department of MedicineUniversity of North CarolinaChapel HillUSA
  2. 2.Department of PediatricsUniversity of North CarolinaChapel HillUSA
  3. 3.Department of Pediatrics, Schneider Children’s HospitalLong Island Jewish Medical CenterLong IslandUSA
  4. 4.Division of Nephrology and HypertensionUniversity of North CarolinaChapel HillUSA