Pediatric Nephrology

, Volume 20, Issue 1, pp 15–18

Calcimimetics—fooling the calcium receptor

Editorial Commentary

DOI: 10.1007/s00467-004-1671-1

Cite this article as:
Ritz, E. Pediatr Nephrol (2005) 20: 15. doi:10.1007/s00467-004-1671-1

Abstract

The cloning and characterization of a calcium-sensing receptor from bovine parathyroid cells has opened up the possibility of modulating the activity of this receptor protein by organic small molecules, either increasing the sensitivity for calcium (calcimimetics) or decreasing the sensitivity (calciolytics), thus suppressing or stimulating parathyroid hormone (PTH) secretion and synthesis, respectively. In primary and secondary hyperparathyroidism, calcimimetics have proven to effectively lower the PTH concentration with minimal side effects. In secondary hyperparathyroidism, a specific advantage is the concomitant lowering of serum calcium and phosphate concentrations.

Keywords

Calcimimetics Renal hyperparathyroidism Chronic renal failure Calcium-sensing receptor 

Copyright information

© IPNA 2004

Authors and Affiliations

  1. 1.Department of Internal Medicine, Division of NephrologyRuperto-Carola UniversityGermany

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