Pediatric Nephrology

, Volume 19, Issue 4, pp 369–377

The post-transplant lymphoproliferative disorder—a literature review

Review

DOI: 10.1007/s00467-003-1392-x

Cite this article as:
Shroff, R. & Rees, L. Pediatr Nephrol (2004) 19: 369. doi:10.1007/s00467-003-1392-x

Abstract

The Epstein-Barr virus (EBV)-induced post-transplant lymphoproliferative disorder (PTLD) affects 1%–10% of all paediatric renal transplant recipients. This is a heterogeneous group of conditions characterised by EBV-driven proliferation of B-lymphocytes in the face of impaired T-cell immune surveillance. The risk factors predisposing to PTLD are becoming better understood, but its pathogenesis and myriad of clinical and histological features remain poorly defined. While new treatment modalities are being tried with variable success, regular EBV surveillance and carefully monitored reduction of immunosuppression remain the mainstay of treatment. In this review, we have presented the current knowledge of this increasingly common complication in renal transplant recipients.

Keywords

Post-transplant lymphoproliferative disorderEpstein-Barr virus

Copyright information

© IPNA 2004

Authors and Affiliations

  1. 1.Department of NephrourologyGreat Ormond Street Hospital for ChildrenLondonUK