Review

Pediatric Nephrology

, Volume 19, Issue 2, pp 130-137

First online:

Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome

  • Jun OhAffiliated withDivision of Nephrology, Albert Einstein College of MedicineDivision of Pediatric Nephrology, Children’s Hospital, University of Heidelberg
  • , Jochen ReiserAffiliated withMassachusetts General Hospital, Renal Unit, Harvard Medical School
  • , Peter MundelAffiliated withDivision of Nephrology, Albert Einstein College of Medicine Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

The visceral glomerular epithelial cell, also known as the podocyte, plays an important role in the maintenance of renal glomerular function. This cell type is highly specialized and its foot processes together with the interposed slit diaphragm (SD) form the final barrier to urinary protein loss. Effacement of foot processes is associated with the development of proteinuria and—if not reversed in a certain time—with permanent deterioration of the glomerular filter. To maintain an intact glomerular filter barrier, podocyte-podocyte interactions and podocyte interactions with the glomerular basement membrane (GBM) are essential. Recent years have highlighted podocyte functions by unraveling the molecular composition of the SD, but have also clarified the important role of the podocyte actin cytoskeleton, and the podocyte-GBM interaction in the development of foot process (FP) effacement. This review provides an update of podocyte functions with respect to novel podocyte-specific proteins and also focuses on the dynamic interaction between the actin cytoskeleton of podocytes, their cell surface receptors and the GBM.

Keywords

Podocytes Foot process effacement Proteinuria Integrins Glomerular basement membrane Dystroglycan