Pediatric Nephrology

, Volume 18, Issue 8, pp 833–837

Use of mycophenolate mofetil in steroid-dependent and -resistant nephrotic syndrome

  • Gina-Marie Barletta
  • William E. Smoyer
  • Timothy E. Bunchman
  • Joseph T. Flynn
  • David B. Kershaw
Brief Report

DOI: 10.1007/s00467-003-1175-4

Cite this article as:
Barletta, GM., Smoyer, W.E., Bunchman, T.E. et al. Pediatr Nephrol (2003) 18: 833. doi:10.1007/s00467-003-1175-4

Abstract

Cyclosporin (Cs-A) is an effective treatment for difficult cases of nephrotic syndrome (NS), but its use can be complicated by renal toxicity and a high incidence of relapses after withdrawal. We reviewed the charts of 10 Cs-A-dependent patients and 4 patients with steroid-dependent nephrotic syndrome (SDNS) not previously treated with Cs-A therapy. All patients had persistent NS, even after prior treatment with oral cyclophosphamide. Of 10 patients treated with Cs-A, 4 had surveillance renal biopsies consistent with Cs-A toxicity, and 8 of 10 had interstitial fibrosis prior to mycophenolate mofetil (MMF). Patients were treated with MMF, at 1,200 mg/m2 per day, in an attempt to allow weaning of Cs-A and/or steroid therapy, and reduce the frequency of relapses. Overall, a significant decrease in frequency of relapses was noted after initiation of MMF therapy. In addition, 5 patients were weaned off Cs-A by 1–2 years of follow-up. One patient was weaned off Cs-A and MMF, and remained in complete remission. However, the subgroup of patients with frequently relapsing SDNS not treated with Cs-A appeared to have a reduction in the number of relapses while on MMF that did not reach statistical significance. Two patients with intractable steroid-resistant NS continued to relapse repeatedly on MMF and Cs-A therapy. We conclude that in this small, single-center, uncontrolled experience, MMF therapy in patients with Cs-A-dependent NS appears to be effective in reducing Cs-A exposure. In addition, MMF appears to significantly decrease the frequency of relapses in this patient population. Further controlled studies are warranted to better define the potential efficacy and side effects of long-term MMF therapy in this setting.

Keywords

Mycophenolate mofetil Steroid-dependent nephrotic syndrome Steroid-resistant nephrotic syndrome Cyclosporin Treatment 

Copyright information

© IPNA 2003

Authors and Affiliations

  • Gina-Marie Barletta
    • 1
  • William E. Smoyer
    • 1
  • Timothy E. Bunchman
    • 1
  • Joseph T. Flynn
    • 1
  • David B. Kershaw
    • 1
  1. 1.University of Michigan Health Sciences CenterMott Children's HospitalAnn ArborUSA