Surgical Endoscopy

, Volume 15, Issue 6, pp 585–588

The impact of gas laparoscopy on abdominal plasminogen activator activity

  • M. Nagelschmidt
  • D. Gerbecks
  • T. Minor
Article

DOI: 10.1007/s004640010282

Cite this article as:
Nagelschmidt, M., Gerbecks, D. & Minor, T. Surg Endosc (2001) 15: 585. doi:10.1007/s004640010282

Abstract

Background: The impairment of intestinal perfusion following induction of a pneumoperitoneum may lead to a reduction of peritoneal tissue plasminogen activator (tPA) activity and a concomitant increased risk of adhesion formation. Methods: Pigs were laparotomized to take peritoneal biposy specimens from the cecum, the ileum, and the abdominal wall. A 15 mmHg pneumoperitoneum was established for 3 h by the insufflation of carbon dioxide (group 2, n = 6) or helium (group 3, n = 6). Group 1 (n = 7) received no gas insufflation. After a 2-h recovery period, additional tissue samples were harvested. Specific tPA activity was then determined in the tissue extracts. Results: During surgery, specific tPA activity decreased in all the samples. As compared with the control group (100%), this reduction was strongly aggravated in the cecum (-67.6%, p < 0.05) and the ileum (-70.8%) of the CO2 group but only slightly aggravated in the helium group. The parietal peritoneum was not specifically affected by gas insufflation. Conclusion: The use of a pneumoperitoneum with carbon dioxide significantly affects peritoneal tPA activity and thus may represent a stimulus for adhesion formation.

Copyright information

© Springer-Verlag New York Inc. 2001

Authors and Affiliations

  • M. Nagelschmidt
    • 1
  • D. Gerbecks
    • 1
  • T. Minor
    • 2
  1. 1.Second Department of Surgery, Biochemical and Experimental Division, University of Cologne, Ostmerheimer Strasse 200, 51109 Cologne, GermanyDE
  2. 2.Division of Surgical Research, Department of Surgery, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, GermanyDE

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