Surgical Endoscopy

, Volume 28, Issue 1, pp 143–155

Fundoplication versus medical management of gastroesophageal reflux disease: systematic review and meta-analysis

  • Nadja Rickenbacher
  • Thomas Kötter
  • Michael M. Kochen
  • Martin Scherer
  • Eva Blozik
Article

DOI: 10.1007/s00464-013-3140-z

Cite this article as:
Rickenbacher, N., Kötter, T., Kochen, M.M. et al. Surg Endosc (2014) 28: 143. doi:10.1007/s00464-013-3140-z

Abstract

Background

Medical, endoscopic, and open/laparoscopic surgical methods are used to treat gastroesophageal reflux disease (GERD). This study aimed to perform a systematic review of randomized controlled trials comparing medical and surgical treatments of GERD in adult patients.

Methods

For the study, MEDLINE and EMBASE (1980–2012) were searched. Two reviewers independently assessed methodologic aspects and extracted data from eligible studies, focusing on patient-relevant outcomes. The primary outcomes were health-related and GERD-specific quality-of-life aspects. Standardized mean differences (SMDs) between treatment groups were calculated and combined using random-effect meta-analysis.

Results

The study identified 11 publications reporting on 7 trials comparing surgical (open or laparoscopic) and medical treatment of GERD. Meta-analysis of both quality-of-life aspects showed a pooled-effect estimate in favor of fundoplication (SMD 0.18; 95 % confidence interval [CI] 0.01–0.35; SMD 0.33; 95 % CI 0.13–0.54). Heartburn and regurgitation were less frequent after surgical intervention. However, a considerable proportion of patients still needed antireflux medication after fundoplication. Nevertheless, the surgical patients were significantly more satisfied with their symptom control and showed higher satisfaction with the treatment received.

Conclusions

This systematic review showed that surgical management of GERD is more effective than medical management with respect to patient-relevant outcomes in the short and medium term. However, long-term studies still are needed to determine whether antireflux surgery is an equivalent alternative to lifelong medical treatment.

Keywords

FundoplicationGastroesophageal refluxAnti-ulcer agentsProton pump inhibitorsReviewMeta-analysis

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Nadja Rickenbacher
    • 1
    • 2
    • 3
  • Thomas Kötter
    • 2
  • Michael M. Kochen
    • 4
  • Martin Scherer
    • 3
  • Eva Blozik
    • 2
    • 3
    • 4
  1. 1.Swiss Federal Office of Public HealthBernSwitzerland
  2. 2.Institute for Social Medicine and EpidemiologyUniversity of LübeckLübeckGermany
  3. 3.Department of Primary Medical CareUniversity Medical Center Hamburg-EppendorfHamburgGermany
  4. 4.Division of Family MedicineUniversity of FreiburgFreiburgGermany