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Sedation methods can determine performance of endoscopic submucosal dissection in patients with gastric neoplasia

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Abstract

Background

Although proper sedation is mandatory for endoscopic procedures such as endoscopic submucosal dissection (ESD), there is no research investigating the effects of sedation on ESD performance and complications. We aimed to evaluate the relationship among sedation methods, clinical outcomes, and complications after ESD for gastric neoplasia.

Methods

We retrospectively reviewed clinical data of 1,367 patients with 1,485 lesions who had undergone ESD for gastric adenoma or early gastric cancer at our tertiary teaching hospital in Seoul, Korea, between January 2008 and May 2011. Of these, 1,035 lesions in 958 patients were included in the intermittent midazolam/propofol injection by endoscopists (IMIE) group, and 450 lesions in 409 patients were included in the continuous propofol infusion with opioid administration by anesthesiologists (CPIA) group.

Results

En bloc resection and complete resection rates were higher in the CPIA group than in the IMIE group (CPIA vs. IMIE; en bloc resection, 99.8 and 95.0 %, P < 0.001; complete resection, 94.2 and 88.3 %, P < 0.001). Duration of procedure was shorter in the CPIA group than in the IMIE group (CPIA vs. IMIE; 48.2 ± 32.5 and 57.6 ± 41.3 min, P < 0.001). In multivariate analysis, sedation method was an independent factor associated with en bloc resection and complete resection. Additionally, sedation with CPIA was not a risk factor for bleeding (P = 0.403) or perforation (P = 0.474); however, aspiration pneumonia developed more frequently in patients sedated with CPIA (CPIA vs. IMIE, 4.4 and 1.5 %, P = 0.002).

Conclusions

Sedation with CPIA can improve ESD performance.

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Acknowledgments

Supported in part by a faculty research grant of Yonsei University College of Medicine for 2011 (Grant 6-2011-0103).

Disclosures

Chan Hyuk Park, Jae Hoon Min, Young-Chul Yoo, Hyunzu Kim, Dong Hoo Joh, Jung Hyun Jo, Suji Shin, Hyuk Lee, Jun Chul Park, Sung Kwan Shin, Yong Chan Lee, and Sang Kil Lee have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul, Republic of Korea

    Chan Hyuk Park, Jae Hoon Min, Dong Hoo Joh, Jung Hyun Jo, Suji Shin, Hyuk Lee, Jun Chul Park, Sung Kwan Shin, Yong Chan Lee & Sang Kil Lee

  2. Department of Anesthesiology, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul, Republic of Korea

    Young-Chul Yoo & Hyunzu Kim

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  1. Chan Hyuk Park
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Correspondence to Sang Kil Lee.

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Chan Hyuk Park and Jae Hoon Min have contributed equally to this study, and both should be considered first author.

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Park, C.H., Min, J.H., Yoo, YC. et al. Sedation methods can determine performance of endoscopic submucosal dissection in patients with gastric neoplasia. Surg Endosc 27, 2760–2767 (2013). https://doi.org/10.1007/s00464-013-2804-z

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