Abstract
Background
Recently, endoscopic submucosal dissection has been carefully applied in early gastric cancer (EGC) with undifferentiated type. However, there are no individual guidelines for endoscopic treatment of EGCs with poorly differentiated tubular adenocarcinoma or signet ring cell carcinoma. The aim of this study was to investigate and compare the clinicopathologic features of these two types of EGC to guide the application of endoscopic treatment.
Methods
Patients to undergo radical gastrectomy for the treatment of EGC were selected for inclusion in this study. Histology was classified according to the Japanese Gastric Cancer Association. Between January 2005 and December 2008, 288 patients with poorly differentiated EGC and 419 patients with signet ring cell EGC were enrolled. Their medical records were reviewed retrospectively.
Results
Compared with signet ring cell EGC, poorly differentiated EGC had higher rates of male gender, old age (≥45 years), large tumor length (>20 mm), ulcer, submucosal invasion, lymphovascular invasion, and lymph node metastasis. In the multivariate analyses, poorly differentiated EGC was significantly associated with ulcer (odds ratio [OR]: 2.4, 95% confidence interval [CI]: 1.5–3.8), submucosal invasion (OR: 3.6, 95% CI: 2.6–5.1) and lymphovascular invasion (OR: 2.0, 95% CI: 1.1–3.6) with a reference of signet ring cell EGC. The independent risk factors for lymph node metastasis were large tumor length, submucosal invasion, and lymphovascular invasion in both types of EGC. Young age was an independent risk factor of lymph node metastasis only in poorly differentiated EGC.
Conclusions
Poorly differentiated EGC has clinicopathologic features that are less favorable to endoscopic treatment than are those of signet ring cell EGC. Therefore, these two types of EGC should be approached separately, not as a united type of undifferentiated histology, during the planning of endoscopic treatment.
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Acknowledgment
This study was supported by a research grant (2006-0177) from the Department of Internal Medicine of Yonsei University College of Medicine, Seoul, Korea.
Disclosures
Hee Man Kim, Kyung Ho Pak, Moon Jae Chung, Jae Hee Cho, Woo Jin Hyung, Sung Hoon Noh, MD, Choong Bai Kim, Yong Chan Lee, Si Young Song, and Sang Kil Lee have no conflict of interests or financial ties to disclose.
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Kim, H.M., Pak, K.H., Chung, M.J. et al. Early gastric cancer of signet ring cell carcinoma is more amenable to endoscopic treatment than is early gastric cancer of poorly differentiated tubular adenocarcinoma in select tumor conditions. Surg Endosc 25, 3087–3093 (2011). https://doi.org/10.1007/s00464-011-1674-5
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DOI: https://doi.org/10.1007/s00464-011-1674-5