, Volume 24, Issue 9, pp 2349-2350
Date: 23 Feb 2010

Double endoscopic intraluminal surgery: superior to ESD for early gastric cancer?

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Early gastric cancer (T1m/smNxM0] treated by surgery alone is a highly curable disease [1]. Current efforts have two goals. In clinical practice, the goal is to develop minimally invasive interventions for improving quality of life (QOL). Endoscopic resections, including mucosal resection (EMR) or submucosal dissection (ESD), and laparoscopic gastrectomy have already been integrated into clinical use in some specialized institutions [2, 3].

In translational research, the goal is discover the genetic alterations that are responsible for the transformation of a normal epithelial cell into intermediate-stage and early invasive gastric cancer. Indeed, changes in DNA sequence cause cancer. In the era of the cancer genome, a new generation of DNA sequencing technology allows the identification of these mutations in the genomes of cancer cells [4]. These advances open the way for the discovery of genetic markers and drugs that may result in effective risk prediction and primary preventive inte ...