Surgical Endoscopy

, Volume 21, Issue 7, pp 1184–1189

Health economic evaluation of therapeutic strategies in patients with idiopathic achalasia: results of a randomized trial comparing pneumatic dilatation with laparoscopic cardiomyotomy


    • Department of General SurgeryBorås Central Hospital
  • E. Johnsson
    • Department of SurgerySahlgrenska University Hospital
  • A. Kjellin
    • Department of SurgeryKarolinska University Hospital
  • M. Ruth
    • Department of SurgerySahlgrenska University Hospital
  • H. Lönroth
    • Department of SurgerySahlgrenska University Hospital
  • M. Andersson
    • Department of RadiologySahlgrenska University Hospital
  • L. Lundell
    • Department of SurgeryKarolinska University Hospital

DOI: 10.1007/s00464-007-9310-0

Cite this article as:
Kostic, S., Johnsson, E., Kjellin, A. et al. Surg Endosc (2007) 21: 1184. doi:10.1007/s00464-007-9310-0



We have prospectively collected information concerning the costs incurred during the management of patients allocated to either forceful dilatation or to an immediate laparoscopic operation because of newly diagnosed achalasia.


Fifty-one patients with newly diagnosed achalasia were randomized to either pneumatic dilatation to a diameter of 30–40 mm or to a laparoscopic myotomy to which was added a posterior partial fundoplication. Follow-ups were scheduled at 1, 3, 6, and 12 months after inclusion. At each follow-up visit a study nurse interviewed the patients regarding symptoms and their quality of life (QoL) and a health economic questionnaire was completed. In the latter questionnaire, patients were asked to report the presence and character of contacts with the healthcare system since the last visit.


In the dilatation group six patients (23%), including the patient who was operated on because of perforation, were classified as failures during the first 12 months of follow-up compared to one (4%) in the myotomy group (p = 0.047). Five of those classified as failures in the dilatation group subsequently had a surgical myotomy and the sixth patient was treated with repeated dilatations. The patient classified as failure in the myotomy group was treated with endoscopic dilatation. The initial treatment cost and the total costs were significantly higher for laparoscopic myotomy compared to a pneumatic dilatation-based strategy (p = 0.0002 and p = 0.0019, respectively) When the total costs were subdivided into the different resources used, we found that the single largest cost item for pneumatic dilatation was that for hospital stay and that for laparoscopic myotomy was the actual operative treatment (operating room time) The cost-effectiveness analysis, relating to the actual treatment failures, revealed that the cost to avoid one treatment failure (incremental cost-effectiveness ratio) amounted to €9239.


The current prospective, controlled clinical trial shows that despite a higher level of clinical efficacy of laparoscopic myotomy to prevent treatment failure in newly diagnosed achalasia, the cost effectiveness of pneumatic dilatation is superior, at least when a reasonable time horizon is applied.


Achalasia Balloon dilatation Myotomy Symptoms Treatment failure Health economic evaluation Laparoscopy

Copyright information

© Springer Science+Business Media, LLC 2007