, Volume 19, Issue 12, pp 1636-1640
Date: 05 Oct 2005

Pneumoperitoneum does not influence trocar site implantation during tumor manipulation in a solid tumor model

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Abstract

Background

The purpose of this study was to assess tumor implantation at abdominal wound sites following manipulation of a solid abdominal tumor.

Methods

GW-39 human colon cancer cells were injected into the omentum of golden Syrian hamsters. At 2 weeks, an omental tumor was harvested and animals were randomized to bivalve (A), crush (B), strip (C), or excision (D), with or without pneumoperitoneum. Four 5-mm trocars were inserted into the abdomen, and the tumor was reinserted through the midline, swept through four quadrants, and removed. The incision was closed and pneumoperitoneum at 7 mmHg was maintained for 10 min. Tumor implantation at wound sites was documented at 7 weeks.

Results

Implantation at trocar sites was 53 and 49% with and without pneumoperitoneum in the manipulated groups (A, B, C), respectively (p = 0.993). Implantation at trocar sites was reduced in the control group (D) at 9 and 10% with and without pneumoperitoneum, respectively (p < 0.001).

Conclusions

Tumor implantation at trocar sites is due to spillage of tumor during manipulation and not to pneumoperitoneum.

Poster presented at the annual meeting of the Society of American Gastrointestinal Endoscopic Surgeons (SAGES), St. Louis, Missouri, USA, April 2001