Surgical Endoscopy And Other Interventional Techniques

, Volume 19, Issue 12, pp 1636–1640

Pneumoperitoneum does not influence trocar site implantation during tumor manipulation in a solid tumor model

  • V. J. Halpin
  • R. A. Underwood
  • D. Ye
  • D. H. Cooper
  • M. Wright
  • S. M. Hickerson
  • W. C. Connett
  • J. M. Connett
  • J. W. Fleshman
Article

DOI: 10.1007/s00464-005-0005-0

Cite this article as:
Halpin, V.J., Underwood, R.A., Ye, D. et al. Surg Endosc (2005) 19: 1636. doi:10.1007/s00464-005-0005-0

Abstract

Background

The purpose of this study was to assess tumor implantation at abdominal wound sites following manipulation of a solid abdominal tumor.

Methods

GW-39 human colon cancer cells were injected into the omentum of golden Syrian hamsters. At 2 weeks, an omental tumor was harvested and animals were randomized to bivalve (A), crush (B), strip (C), or excision (D), with or without pneumoperitoneum. Four 5-mm trocars were inserted into the abdomen, and the tumor was reinserted through the midline, swept through four quadrants, and removed. The incision was closed and pneumoperitoneum at 7 mmHg was maintained for 10 min. Tumor implantation at wound sites was documented at 7 weeks.

Results

Implantation at trocar sites was 53 and 49% with and without pneumoperitoneum in the manipulated groups (A, B, C), respectively (p = 0.993). Implantation at trocar sites was reduced in the control group (D) at 9 and 10% with and without pneumoperitoneum, respectively (p < 0.001).

Conclusions

Tumor implantation at trocar sites is due to spillage of tumor during manipulation and not to pneumoperitoneum.

Keywords

Colon cancerLaparoscopyPneumoperitoneumSurgical techniqueMetastases

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • V. J. Halpin
    • 1
  • R. A. Underwood
    • 1
  • D. Ye
    • 1
  • D. H. Cooper
    • 1
  • M. Wright
    • 1
  • S. M. Hickerson
    • 1
  • W. C. Connett
    • 1
  • J. M. Connett
    • 1
  • J. W. Fleshman
    • 1
  1. 1.Department of SurgeryWashington University School of MedicineSt. LouisUSA