Surgical Endoscopy And Other Interventional Techniques

, Volume 16, Issue 9, pp 1292–1296

Impact of dopamine and endothelin-1 antagonism on portal venous blood flow during laparoscopic surgery

  • Z. G. Kim
  • E. Sanli
  • L. Brinkmann
  • M. Lorenz
  • C. N. Gutt
Original Articles

DOI: 10.1007/s00464-001-9208-1

Cite this article as:
Kim, Z.G., Sanli, E., Brinkmann, L. et al. Surg Endosc (2002) 16: 1292. doi:10.1007/s00464-001-9208-1

Abstract

Background

Recent data indicate that pneumoperitoneal carbondioxide (CO2) insufflation impairs hepatic macro- and microcirculation. Whether dopamine and endothelin-1 (ET-1) antagonists might restore liver blood during laparoscopic surgery has not yet been investigated.

Methods

For this study, 30 male WAG/Rij rats were randomized into two groups to obtain pneumoperitoneum with CO2 (n=15) or helium (n=15). All the animals were implanted with a polyethylene-50 cannula into the right vena jugularis and a Doppler ultrasound flow probe around the portal vein. In each group, the rats were administered dopamine (n=5); JKC-10, JKC-301, which is a selective endothelin-1 (ET-1) antagonist (n=5), or sodium chloride as a control (n=5). Portal blood flow was measured during intraabdominal pressures 2 to 12 mmHg. Data were analyzed using the Kruskal-Wallis h-test.

Results

The application of dopamine and ET-1 antagonists significantly improved portal blood flow over that of the control animals (p<0.05). No significant differences were found between CO2 and helium insufflation (p>0.05).

Conclusions

Dopamine and ET-1 antagonism restore portal blood flow during laparoscopic surgery independantly of the insufflation gas. Whether improved hepatic perfusion might have beneficial effects on liver function needs further investigation.

Key words

LaparoscopyPneumoperitoneumPortal blood flowDopamineEndothelin antagonism

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Z. G. Kim
    • 1
  • E. Sanli
    • 1
  • L. Brinkmann
    • 1
  • M. Lorenz
    • 1
  • C. N. Gutt
    • 1
  1. 1.Department of General and Vascular SurgeryJohann Wolfgang Goethe UniversityFrankfurt/MainGermany