Bioprocess and Biosystems Engineering

, Volume 33, Issue 4, pp 457–463

Hydrophobic modification of sodium alginate and its application in drug controlled release

  • Bolong Yao
  • Caihua Ni
  • Cheng Xiong
  • Changping Zhu
  • Bo Huang
Original Paper

DOI: 10.1007/s00449-009-0349-2

Cite this article as:
Yao, B., Ni, C., Xiong, C. et al. Bioprocess Biosyst Eng (2010) 33: 457. doi:10.1007/s00449-009-0349-2

Abstract

Sodium alginate was hydrophobically modified by coupling of polybutyl methacrylate onto the alginate. The polybutyl methacrylate was previously prepared through polymerization of butyl methacrylate in the presence of 2-amino-ethanethiol as a chain transfer agent. The structure of the product was characterized by Fourier-transformed infrared spectrometry, nuclear magnetic resonance (1HNMR) and thermogravimetry. The result of fluorescence analysis showed that the hydrophobicity of the modified alginate was obviously increased. The modified alginate conjugate was used for immobilization of bovine serum albumin in the presence of calcium chloride. In addition, the release behavior of the drug-loaded alginate in deionized water and Tris–HCl buffer solution (pH 7.2) was investigated. It was found that the modified sodium alginate possessed prolonged release behavior compared to unmodified sodium alginate, and it had potential application in controlled release as a drug carrier.

Keywords

Sodium alginateControlled releaseHydrophobic modificationPolybutyl methacrylate

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Bolong Yao
    • 1
    • 2
  • Caihua Ni
    • 1
    • 2
  • Cheng Xiong
    • 1
  • Changping Zhu
    • 2
  • Bo Huang
    • 2
  1. 1.School of Chemical and Material EngineeringJiangnan UniversityWuxiChina
  2. 2.State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, College of Computer and Information EngineeringHohai UniversityNanjingChina