Original Paper

Bioprocess and Biosystems Engineering

, Volume 26, Issue 6, pp 347-351

First online:

Recent developments in the monitoring, modeling and control of biological production systems

  • Carl-Fredrik MandeniusAffiliated withDivision of Biotechnology, Linköping University Email author 

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Current trends in the development of methods for monitoring, modeling and controlling biological production systems are reviewed from a bioengineering perspective. The ability to measure intracellular conditions in bioprocesses using genomics and other bioinformatics tools is addressed. Devices provided via micromachining techniques and new real-time optical technology are other novel methods that may facilitate biosystem engineering. Mathematical modeling of data obtained from bioinformatics or real-time monitoring methods are necessary in order to handle the dense flows of data that are generated. Furthermore, control methods must be able to cope with these data flows in efficient ways that can be implemented in plant-wide computer communication systems.


Genomics and proteomics Chemometrics Multivariate process control In situ optical sensors Miniaturized devices Control models