Cell and Tissue Research

, Volume 294, Issue 3, pp 415–420

Expression of the gap-junction connexins 26 and 30 in the rat cochlea

  • J. Lautermann
  • Wouter-Jan F. ten Cate
  • Petra Altenhoff
  • Ruth Grümmer
  • Otto Traub
  • H.-G. Frank
  • Klaus Jahnke
  • Elke Winterhager
REGULAR ARTICLE

DOI: 10.1007/s004410051192

Cite this article as:
Lautermann, J., ten Cate, WJ., Altenhoff, P. et al. Cell Tissue Res (1998) 294: 415. doi:10.1007/s004410051192

Abstract

Gap junction channels which are responsible for direct intercellular communication are composed of connexin proteins. Different connexins are distributed in a tissue-specific manner. Up to now only connexin26 has been identified to be widely expressed in the inner ear. In order to investigate the role of additional gap junction proteins, the expression of connexin30 and 43 was investigated in the rat cochlea. Connexin26 and connexin30 were both expressed in the spiral limbus, the spiral ligament, the stria vascularis and between supporting cells of the organ of Corti. Double-labeling experiments suggest that both connexins are partly colocalized between cells. Weak staining of connexin43 could only be detected in the stria vascularis, the spiral ligament and between organ of Corti supporting cells. The corresponding transcripts for connexin26, 30 and 43 could be detected by Northern blot analysis. The expression of different gap junction channels in the cochlea suggests functional diversity. Gap junctions in the inner ear may control ion concentrations of cochlear fluids or act as conduits through which glucose and other metabolites diffuse.

Key words Inner ear Gap junctions Connexins Rat (Wistar) 

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • J. Lautermann
    • 1
  • Wouter-Jan F. ten Cate
    • 1
  • Petra Altenhoff
    • 1
  • Ruth Grümmer
    • 2
  • Otto Traub
    • 3
  • H.-G. Frank
    • 4
  • Klaus Jahnke
    • 1
  • Elke Winterhager
    • 2
  1. 1.Department of Otorhinolaryngology, University of Essen, Hufelandstrasse 55, D-45122 Essen, Germany Tel.: +49 201 723 2942; Fax: +49 201 723 5903DE
  2. 2.Department of Anatomy, University of Essen, GermanyDE
  3. 3.Department of Genetics, University of Bonn, GermanyDE
  4. 4.Department of Anatomy, Technical University of Aachen, GermanyDE

Personalised recommendations