Cell and Tissue Research

, Volume 290, Issue 2, pp 197–200

Pax-2 in the chiasm

  • G. Alvarez-Bolado
  • M. Schwarz
  • P. Gruss

DOI: 10.1007/s004410050923

Cite this article as:
Alvarez-Bolado, G., Schwarz, M. & Gruss, P. Cell Tissue Res (1997) 290: 197. doi:10.1007/s004410050923

Abstract. 

Pax genes are expressed in specific patterns in the nervous system during development and in the adult. Recent findings suggest a link between the expression of Pax-2 and axonal guidance. Mice with a targeted deletion of Pax-2 are an excellent tool for studying axonal pathfinding at the molecular level, especially with respect to the optic chiasm. The date reviewed here suggest that Pax-2 regulates the expression of surface molecules involved in contact attraction and that the mutual regulation of the expression of Pax-2 and the Sonic hedgehog gene is of importance in the formation of the chiasm region.

Key words: Pax-2Optic chiasmAxonal guidanceSonic hedgehogMutant miceZebrafish

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • G. Alvarez-Bolado
    • 1
  • M. Schwarz
    • 1
  • P. Gruss
    • 1
  1. 1.Max-Planck Institut für biophysikalische Chemie, Abt. Molekulare Zellbiologie 160, Am Fassberg, D-37077 Göttingen, GermanyDE