Cell and Tissue Research

, Volume 284, Issue 3, pp 347–354

Laminar segregation of odorant receptor expression in the olfactory epithelium

Authors

  • Jörg Strotmann
    • University Stuttgart-Hohenheim, Institute of Zoophysiology, Garbenstrasse 30, D-70593 Stuttgart, Germany
  • Sidonie Konzelmann
    • University Stuttgart-Hohenheim, Institute of Zoophysiology, Garbenstrasse 30, D-70593 Stuttgart, Germany
  • Heinz Breer
    • University Stuttgart-Hohenheim, Institute of Zoophysiology, Garbenstrasse 30, D-70593 Stuttgart, Germany

DOI: 10.1007/s004410050595

Cite this article as:
Strotmann, J., Konzelmann, S. & Breer, H. Cell Tissue Res (1996) 284: 347. doi:10.1007/s004410050595

Abstract.

The laminar segregation of sensory neurons expressing a distinct receptor type was determined in tissue sections through the olfactory epithelium by in situ hybridization employing receptor-specific probes. Reactive cells were restricted to the mid-zone of the epithelium, the location of mature neurons. Detailed analyses revealed that neurons expressing a distinct receptor type were distributed in a characteristic manner throughout the layers of the neuronal zone, i.e. they were preferentially located in a particular laminar zone of the epithelium. Cells expressing different receptor types displayed different distribution patterns. In addition, sets of several reactive neurons within the same laminar zone were found to be arranged in an orderly fashion and were positioned at well-defined intervals. These results indicate that the localization of sensory neurons expressing a distinct receptor type is under stringent control leading to characteristic expression patterns.

Key words: Olfactory system Receptors membrane Gene expression Sensory cells Segregation laminar Rat (Wistar)

Copyright information

© Springer-Verlag Berlin Heidelberg 1996