Cell and Tissue Research

, Volume 365, Issue 3, pp 495–506

Epithelial-mesenchymal transition in tissue repair and fibrosis

  • Rivka C. Stone
  • Irena Pastar
  • Nkemcho Ojeh
  • Vivien Chen
  • Sophia Liu
  • Karen I. Garzon
  • Marjana Tomic-Canic
Review

DOI: 10.1007/s00441-016-2464-0

Cite this article as:
Stone, R.C., Pastar, I., Ojeh, N. et al. Cell Tissue Res (2016) 365: 495. doi:10.1007/s00441-016-2464-0

Abstract

The epithelial-mesenchymal transition (EMT) describes the global process by which stationary epithelial cells undergo phenotypic changes, including the loss of cell-cell adhesion and apical-basal polarity, and acquire mesenchymal characteristics that confer migratory capacity. EMT and its converse, MET (mesenchymal-epithelial transition), are integral stages of many physiologic processes and, as such, are tightly coordinated by a host of molecular regulators. Converging lines of evidence have identified EMT as a component of cutaneous wound healing, during which otherwise stationary keratinocytes (the resident skin epithelial cells) migrate across the wound bed to restore the epidermal barrier. Moreover, EMT plays a role in the development of scarring and fibrosis, as the matrix-producing myofibroblasts arise from cells of the epithelial lineage in response to injury but are pathologically sustained instead of undergoing MET or apoptosis. In this review, we summarize the role of EMT in physiologic repair and pathologic fibrosis of tissues and organs. We conclude that further investigation into the contribution of EMT to the faulty repair of fibrotic wounds might identify components of EMT signaling as common therapeutic targets for impaired healing in many tissues.

Graphical Abstract

Model for injury-triggered EMT activation in physiologic wound repair (left) and fibrotic wound healing (right)

Keywords

Epithelial-mesenchymal transitionWound healingFibrosisKeratinocytesDermal fibroblasts

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Rivka C. Stone
    • 1
    • 2
  • Irena Pastar
    • 1
  • Nkemcho Ojeh
    • 1
    • 3
  • Vivien Chen
    • 1
  • Sophia Liu
    • 1
  • Karen I. Garzon
    • 1
  • Marjana Tomic-Canic
    • 1
  1. 1.Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous SurgeryUniversity of Miami Miller School of MedicineMiamiUSA
  2. 2.The Research Residency Program, Department of Dermatology and Cutaneous SurgeryUniversity of Miami Miller School of MedicineMiamiUSA
  3. 3.Faculty of Medical SciencesThe University of the West IndiesBridgetownBarbados