Cell and Tissue Research

, Volume 354, Issue 2, pp 343-354

First online:

Novel mechanisms of tube-size regulation revealed by the Drosophila trachea

  • Li ZuoAffiliated withDepartment of Biological Sciences, Oakland UniversitySchool of Health and Rehabilitation Sciences, The Ohio State College of Medicine, The Ohio State University Wexner Medical Center
  • , Ekaterini IordanouAffiliated withDepartment of Biological Sciences, Oakland University
  • , Rachana R. ChandranAffiliated withDepartment of Biological Sciences, Oakland University
  • , Lan JiangAffiliated withDepartment of Biological Sciences, Oakland UniversityDodge Hall of Engineering 322 Email author 

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The size of various tubes within tubular organs such as the lung, vascular system and kidney must be finely tuned for the optimal delivery of gases, nutrients, waste and cells within the entire organism. Aberrant tube sizes lead to devastating human illnesses, such as polycystic kidney disease, fibrocystic breast disease, pancreatic cystic neoplasm and thyroid nodules. However, the underlying mechanisms that are responsible for tube-size regulation have yet to be fully understood. Therefore, no effective treatments are available for disorders caused by tube-size defects. Recently, the Drosophila tracheal system has emerged as an excellent in vivo model to explore the fundamental mechanisms of tube-size regulation. Here, we discuss the role of the apical luminal matrix, cell polarity and signaling pathways in regulating tube size in Drosophila trachea. Previous studies of the Drosophila tracheal system have provided general insights into epithelial tube morphogenesis. Mechanisms that regulate tube size in Drosophila trachea could be well conserved in mammalian tubular organs. This knowledge should greatly aid our understanding of tubular organogenesis in vertebrates and potentially lead to new avenues for the treatment of human disease caused by tube-size defects.


Trachea Tube size Luminal matrix Apical secretion Cell polarity Endocytosis Drosophila