Cell and Tissue Research

, Volume 353, Issue 2, pp 231–244

Development of diagnostic and treatment strategies for glaucoma through understanding and modification of scleral and lamina cribrosa connective tissue


DOI: 10.1007/s00441-013-1603-0

Cite this article as:
Quigley, H.A. & Cone, F.E. Cell Tissue Res (2013) 353: 231. doi:10.1007/s00441-013-1603-0


Considerable evidence indicates that the state of ocular connective tissues and their response in glaucomatous disease affect the degree of glaucoma damage. Both experimental and clinical data suggest that improved diagnostic and prognostic information can be derived from the assessment of the mechanical responsiveness of the sclera and lamina cribrosa to intraocular pressure (IOP). Controlled mutagenesis of the sclera has produced a mouse strain that is relatively resistant to increased IOP. Alteration of the baseline scleral state can be accomplished through either increased cross-linking of fibrillar components or their reduction. The sclera is a dynamic structure, altering its structure and behavior in response to IOP change. The biochemical pathways that control these responses are fertile areas for new glaucoma treatments.


GlaucomaScleraPathogenesisRetinal ganglion cellTherapy

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Glaucoma Center of Excellence, Wilmer InstituteJohns Hopkins University School of MedicineBaltimoreUSA