Cell and Tissue Research

, Volume 351, Issue 2, pp 255–268

Matrix metalloproteinases and epidermal wound repair

  • Vera L. Martins
  • Matthew Caley
  • Edel A. O’Toole
Review

DOI: 10.1007/s00441-012-1410-z

Cite this article as:
Martins, V.L., Caley, M. & O’Toole, E.A. Cell Tissue Res (2013) 351: 255. doi:10.1007/s00441-012-1410-z

Abstract

Epidermal wound healing is a complex and highly coordinated process where several different cell types and molecules, such as growth factors and extracellular matrix (ECM) components, play an important role. Among the many proteins that are essential for the restoration of tissue integrity is the metalloproteinase (MMP) family. MMPs can act on ECM and non-ECM components affecting degradation and modulation of the ECM, growth-factor activation and cell–cell and cell–matrix signalling. MMPs are secreted by different cell types such as keratinocytes, fibroblasts and inflammatory cells at different stages and locations during wound healing, thereby regulating this process in a very coordinated and controlled way. In this article, we review the role of MMPs and their inhibitors (TIMPs), as well as the disintegrin and metalloproteinase with the thrombospondin motifs (ADAMs) family, in epithelial wound repair.

Keywords

Wound Epidermis Keratinocyte MMP TIMPs 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Vera L. Martins
    • 1
  • Matthew Caley
    • 1
  • Edel A. O’Toole
    • 1
  1. 1.Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and DentistryQueen Mary University of LondonLondonUK