Review

Cell and Tissue Research

, Volume 347, Issue 3, pp 665-676

Musculoskeletal tissue engineering by endogenous stem/progenitor cells

  • Hemin NieAffiliated withTissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center
  • , Chang Hun LeeAffiliated withTissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center
  • , Jiali TanAffiliated withTissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center
  • , Chuanyong LuAffiliated withTissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center
  • , Avital MendelsonAffiliated withTissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center
  • , Mo ChenAffiliated withTissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center
  • , Mildred C. EmbreeAffiliated withTissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center
  • , Kimi KongAffiliated withTissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center
  • , Bhranti ShahAffiliated withTissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center
    • , Shuang WangAffiliated withTissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center
    • , Shoko ChoAffiliated withTissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center
    • , Jeremy J. MaoAffiliated withTissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

From its inception, tissue engineering has had three tenets: cells, biomaterial scaffolds and signaling molecules. Among the triad, cells are the center piece, because cells are the building blocks of tissues. For decades, cell therapies have focused on the procurement, manipulation and delivery of healthy cells for the treatment of diseases or trauma. Given the complexity and potential high cost of cell delivery, there is recent and surging interest to orchestrate endogenous cells for tissue regeneration. Biomaterial scaffolds are vital for many but not all, tissue-engineering applications and serve to accommodate or promote multiple cellular functions. Signaling molecules can be produced by transplanted cells or endogenous cells, or delivered specifically to regulate cell functions. This review highlights recent work in tissue engineering and cell therapies, with a focus on harnessing the capacity of endogenous cells as an alternative or adjunctive approach for tissue regeneration.

Keywords

Cell delivery Cell homing Progenitor cells Stem cells Tissue engineering Tissue regeneration