Cell and Tissue Research

, Volume 343, Issue 1, pp 153–165

NF-κB and STAT3 signaling hubs for lung innate immunity

Authors

  • Lee J. Quinton
    • The Pulmonary CenterBoston University School of Medicine
    • The Pulmonary CenterBoston University School of Medicine
Review

DOI: 10.1007/s00441-010-1044-y

Cite this article as:
Quinton, L.J. & Mizgerd, J.P. Cell Tissue Res (2011) 343: 153. doi:10.1007/s00441-010-1044-y

Abstract

Innate immune responses to lung pathogens involve the coordinated expression of myriad affector and effector molecules of innate immunity, which must be induced and appropriately regulated in response to diverse stimuli generated by microbes or the infected host. Many intercellular and intracellular signaling pathways are involved, but we propose NF-κB and STAT3 transcription factors to be especially important signaling hubs for integrating these pathways to orchestrate effective host defense without excessive inflammatory injury.

Keywords

PneumoniaInnate immunityNF-ĸBSTAT3Transcriptional regulation

Copyright information

© Springer-Verlag 2010