Cell and Tissue Research

, Volume 343, Issue 1, pp 97–106

Monocyte and macrophage heterogeneity and Toll-like receptors in the lung


  • David Schneberger
    • Department of Veterinary Biomedical SciencesUniversity of Saskatchewan
  • Karin Aharonson-Raz
    • Koret School of Veterinary MedicineThe Hebrew University of Jerusalem
    • Department of Veterinary Biomedical SciencesUniversity of Saskatchewan

DOI: 10.1007/s00441-010-1032-2

Cite this article as:
Schneberger, D., Aharonson-Raz, K. & Singh, B. Cell Tissue Res (2011) 343: 97. doi:10.1007/s00441-010-1032-2


Mononuclear phagocytes are crucial components of the innate host defense system. Cells such as macrophages and monocytes phagocytose and process pathogens, produce inflammatory mediators, and link the innate and the adaptive immune systems. The role of innate immune receptors such as Toll-like receptors (TLRs) in the recognition of pathogens is critical for mounting a precise and targeted immune response. This review focuses attention on the development of monocytes and macrophages, various populations of macrophages, and the expression and function of TLRs on macrophages.


LungInnate immunityPulmonary intravascular macrophagesToll-like receptorsHeterogeneity

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© Springer-Verlag 2010