Cell and Tissue Research

, Volume 339, Issue 1, pp 111-120

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes

  • Johanna IvaskaAffiliated withVTT Technical Research Centre of Finland, Medical BiotechnologyCentre for Biotechnology, Turku UniversityDepartment of Biochemistry and Food Chemistry, University of Turku
  • , Jyrki HeinoAffiliated withDepartment of Biochemistry and Food Chemistry, University of Turku Email author 


The emergence of multicellular animals could only take place once evolution had produced molecular mechanisms for cell adhesion and communication. Today, all metazoans express integrin-type adhesion receptors and receptors for growth factors. Integrins recognize extracellular matrix proteins and respective receptors on other cells and, following ligand binding, can activate the same cellular signaling pathways that are regulated by growth factor receptors. Recent reports have indicated that the two receptor systems also collaborate in many other ways. Here, we review the present information concerning the role of integrins as assisting growth factor receptors and the interplay between the receptors in cell signaling and in the orchestration of receptor recycling.


Integrin Cell adhesion Growth factor Signaling Endocytosis