Cell and Tissue Research

, Volume 335, Issue 1, pp 223–240

Vascular endothelium in cancer

Review

DOI: 10.1007/s00441-008-0707-4

Cite this article as:
Nikitenko, L.L. Cell Tissue Res (2009) 335: 223. doi:10.1007/s00441-008-0707-4

Abstract

The vascular endothelium plays an essential role during organogenesis and in tissue homeostasis. Growing evidence also supports its essential and complex role in tumour biology and cancer progression. In particular, excessive proliferation and transformation or dysfunction of endothelial cells leads to pathological (lymph)angiogenesis or vascular malfunctions, which are hallmarks of neoplastic and malignant disorders. Reciprocal interactions between endothelial cells and the local tumour microenvironment may regulate tumour progression and resistance to anti-cancer therapies in a tumour-type-specific manner.

Keywords

AngiogenesisCancerEndothelial cellLymphangiogenesisNeoplasmKaposi’s sarcoma

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Viral Oncology Group, UCL Cancer InstituteUniversity College LondonLondonUK