Cell and Tissue Research

, 326:249

Synapse development: still looking for the forest, still lost in the trees

  • Craig C. Garner
  • Clarissa L. Waites
  • Noam E. Ziv
Review

DOI: 10.1007/s00441-006-0278-1

Cite this article as:
Garner, C.C., Waites, C.L. & Ziv, N.E. Cell Tissue Res (2006) 326: 249. doi:10.1007/s00441-006-0278-1

Abstract

Synapse development in the vertebrate central nervous system is a highly orchestrated process occurring not only during early stages of brain development, but also (to a lesser extent) in the mature nervous system. During development, the formation of synapses is intimately linked to the differentiation of neuronal cells, the extension of their axons and dendrites, and the course wiring of the nervous system. Subsequently, the stabilization, elimination, and strengthening of synaptic contacts is coupled to the refinement of axonal and dendritic arbors, to the establishment of functionally meaningful connections, and probably also to the day-to-day acquisition, storage, and retrieval of memories, higher order thought processes, and behavioral patterns.

Keywords

SynapseSynapse developmentAxonal arborsDendritic arborsSynapse assembly

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Craig C. Garner
    • 1
  • Clarissa L. Waites
    • 1
  • Noam E. Ziv
    • 2
  1. 1.Department of Psychiatry and Behavioral Science, Nancy Pritzer LaboratoryStanford UniversityPalo AltoUSA
  2. 2.The Department of Physiology, Technion Faculty of MedicineThe Rappaport Family Institute for Research in the Medical SciencesHaifaIsrael