, Volume 326, Issue 2, pp 273-285

The genetics of synapse formation and function in Caenorhabditis elegans

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The aim of this review is to introduce the reader to Caenorhabditis elegans as a model system, especially with respect to studies of synapse formation and function. We begin by giving a short description of the structure of the nervous system of C. elegans. As most of the findings that are reviewed here have emerged from studies of neuromuscular junctions (NMJs), two prominent NMJs of C. elegans will be outlined briefly. In addition, we summarize new findings that have added to our understanding of NMJs during the last few years.

Work at the Baumeister laboratory is supported by grants from the European Union (APOPIS), DFG1364/3-3, the Fonds der Chemischen Industrie and the “Qualitätsoffensive Programm” of the State of Baden-Württemberg.