Regular Article

Cell and Tissue Research

, Volume 322, Issue 3, pp 365-378

First online:

Expression patterns of nm23 genes during mouse organogenesis

  • Lilian AmreinAffiliated withEA DRED 483, Laboratoire de Biologie de la Différenciation et du Développement, Université Victor Ségalen
  • , Perrine BarraudAffiliated withEA DRED 483, Laboratoire de Biologie de la Différenciation et du Développement, Université Victor Ségalen
  • , Jean-Yves DanielAffiliated withEA DRED 483, Laboratoire de Biologie de la Différenciation et du Développement, Université Victor Ségalen
  • , Yves PérelAffiliated withEA DRED 483, Laboratoire de Biologie de la Différenciation et du Développement, Université Victor Ségalen
  • , Marc LandryAffiliated withINSERM E 358, Institut Francois Magendie, Université Bordeaux 2 Email author 

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Abstract

Nucleoside di-phosphate kinase enzyme (NDPK) isoforms, encoded by the nm23 family of genes, may be involved in various cellular differentiation and proliferation processes. We have therefore analyzed the expression of nm23-M1, -M2, -M3, and -M4 during embryonic mouse development. In situ hybridization data has revealed the differential expression of nm23 mRNA during organogenesis. Whereas nm23-M1 and -M3 are preferentially expressed in the nervous and sensory systems, nm23-M2 mRNA is found ubiquitously. Irrespective of the developmental state studied, nm23-M4 mRNA is only expressed at low levels in a few embryonic organs. In the cerebellum and cerebral cortex, nm23-M1, -M2, and -M3 are present in the neuronal differentiation layer, whereas nm23-M4 mRNA is distributed in the proliferating layer. Thus, nm23 mRNA is differentially expressed, and the diverse NDPK isoforms are sequentially involved in various developmental processes.

Keywords

Nucleoside diphosphate kinase nm23 Embryonic development Nervous system Differential expression Mouse (C57BL/6)