Cell and Tissue Research

, Volume 322, Issue 3, pp 365–378

Expression patterns of nm23 genes during mouse organogenesis

  • Lilian Amrein
  • Perrine Barraud
  • Jean-Yves Daniel
  • Yves Pérel
  • Marc Landry
Regular Article

DOI: 10.1007/s00441-005-0036-9

Cite this article as:
Amrein, L., Barraud, P., Daniel, JY. et al. Cell Tissue Res (2005) 322: 365. doi:10.1007/s00441-005-0036-9

Abstract

Nucleoside di-phosphate kinase enzyme (NDPK) isoforms, encoded by the nm23 family of genes, may be involved in various cellular differentiation and proliferation processes. We have therefore analyzed the expression of nm23-M1, -M2, -M3, and -M4 during embryonic mouse development. In situ hybridization data has revealed the differential expression of nm23 mRNA during organogenesis. Whereas nm23-M1 and -M3 are preferentially expressed in the nervous and sensory systems, nm23-M2 mRNA is found ubiquitously. Irrespective of the developmental state studied, nm23-M4 mRNA is only expressed at low levels in a few embryonic organs. In the cerebellum and cerebral cortex, nm23-M1, -M2, and -M3 are present in the neuronal differentiation layer, whereas nm23-M4 mRNA is distributed in the proliferating layer. Thus, nm23 mRNA is differentially expressed, and the diverse NDPK isoforms are sequentially involved in various developmental processes.

Keywords

Nucleoside diphosphate kinasenm23Embryonic developmentNervous systemDifferential expressionMouse (C57BL/6)

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Lilian Amrein
    • 1
  • Perrine Barraud
    • 1
  • Jean-Yves Daniel
    • 1
  • Yves Pérel
    • 1
  • Marc Landry
    • 2
  1. 1.EA DRED 483, Laboratoire de Biologie de la Différenciation et du DéveloppementUniversité Victor SégalenBordeaux CedexFrance
  2. 2.INSERM E 358, Institut Francois MagendieUniversité Bordeaux 2Bordeaux CedexFrance