Human Genetics

, Volume 103, Issue 1, pp 57–59

Negative association between asthma and variants of CC16(CC10) on chromosome 11q13 in British and Japanese populations

  • P.-S. Gao
  • X.-Q. Mao
  • M. Kawai
  • T. Enomoto
  • S. Sasaki
  • O. Tanabe
  • K. Yoshimura
  • S. R. Shaldon
  • Y. Dake
  • H. Kitano
  • P. Coull
  • T. Shirakawa
  • J. M. Hopkin
Original Investigation

DOI: 10.1007/s004390050783

Cite this article as:
Gao, PS., Mao, XQ., Kawai, M. et al. Hum Genet (1998) 103: 57. doi:10.1007/s004390050783

Abstract

The gene encoding Clara cell-derived inflammatory molecule CC16 has been cited as a candidate gene for atopic asthma on chromosome 11q13. A genetic association study was performed with variants of the CC16 gene on chromosome 11q13 in relation to asthma in British (n=275) and Japanese (n=300) populations. No significant association was found between asthma and CC16 genotypes, irrespective of atopic status in these two populations. These data suggest that CC16 might not be the major locus for asthma on 11q13.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • P.-S. Gao
    • 1
  • X.-Q. Mao
    • 1
  • M. Kawai
    • 2
  • T. Enomoto
    • 3
  • S. Sasaki
    • 4
  • O. Tanabe
    • 5
  • K. Yoshimura
    • 5
  • S. R. Shaldon
    • 1
  • Y. Dake
    • 3
  • H. Kitano
    • 6
  • P. Coull
    • 7
  • T. Shirakawa
    • 1
  • J. M. Hopkin
    • 1
  1. 1.Osler Chest Unit, Churchill Hospital, Oxford OX3 7LJ, UK e-mail: qjmed@radius.jr2.ox.ac.uk, Tel.: +44-1865-225224, Fax: +44-1865-767659GB
  2. 2.Kyoto Preventive Medical Centre, Kyoto, JapanJP
  3. 3.Department of ORL, Japanese Red Cross Society, Wakayama Medical Center, Wakayama, JapanJP
  4. 4.Department of Pediatrics, Osaka College of Medicine, Takatsuki, JapanJP
  5. 5.Department of Gene Therapy, Institute of DNA Medicine, The Jikei University, School of Medicine, Tokyo, JapanJP
  6. 6.Department of ORL & Neck and Head Surgery, Shiga University of Medical Science, Ohtsu, JapanJP
  7. 7.Immunology Laboratory Unit, Churchill Hospital, Oxford, UKGB

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