Human Genetics

, Volume 103, Issue 1, pp 48–50

Elite endurance athletes and the ACE I allele – the role of genes in athletic performance

  • George Gayagay
  • Bing Yu
  • Brett Hambly
  • Tanya Boston
  • Alan Hahn
  • David S. Celermajer
  • R. J. Trent
Original investigation

DOI: 10.1007/s004390050781

Cite this article as:
Gayagay, G., Yu, B., Hambly, B. et al. Hum Genet (1998) 103: 48. doi:10.1007/s004390050781

Abstract

Genetic markers that might contribute to the making of an elite athlete have not been identified. Potential candidate genes might be found in the renin-angiotensin pathway, which plays a key role in the regulation of both cardiac and vascular physiology. In this study, DNA polymorphisms derived from the angiotensin converting enzyme (ACE), the angiotensin type 1 receptor (AT1) and the angiotensin type 2 receptor (AT2) were studied in 64 Australian national rowers. Compared with a normal population, the rowers had an excess of the ACE I allele (P<0.02) and the ACE II genotype (P=0.03). The ACE I allele is a genetic marker that might be associated with athletic excellence. It is proposed that the underlying mechanism relates to a healthier cardiovascular system.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • George Gayagay
    • 1
  • Bing Yu
    • 1
  • Brett Hambly
    • 2
  • Tanya Boston
    • 3
  • Alan Hahn
    • 3
  • David S. Celermajer
    • 4
  • R. J. Trent
    • 1
  1. 1.Department of Molecular & Clinical Genetics, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia e-mail: rtrent@med.usyd.edu.au, Fax: +61-2-95157595AU
  2. 2.Department of Pathology, University of Sydney NSW 2006, AustraliaAU
  3. 3.Australian Institute of Sport, Canberra ACT 2617, AustraliaAU
  4. 4.Department of Cardiology, Royal Prince Alfred Hospital, Camperdown NSW 2050, AustraliaAU