Human Genetics

, Volume 102, Issue 4, pp 493–494

Refined genetic mapping of autosomal dominant retinitis pigmentosa locus RP18 reduces the critical region to 2 cM between D1S442 and D1S2858 on chromosome 1q

  • Su-ying Xu
  • Thomas Rosenberg
  • A. Gal
Rapid communication

DOI: 10.1007/s004390050728

Cite this article as:
Xu, S., Rosenberg, T. & Gal, A. Hum Genet (1998) 102: 493. doi:10.1007/s004390050728

Abstract

Linkage analysis was performed on a large Danish family to refine the position of RP18, the locus for autosomal dominant retinitis pigmentosa, mapped previously between D1S534 and D1S305 in chromosome 1p13–q21. We genotyped the family members for five microsatellite-type DNA polymorphisms and mapped RP18 between D1S422 and D1S2858 to a region of less than 2 cM. No obvious candidate gene has yet been assigned to the chromosomal interval defined here.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Su-ying Xu
    • 1
  • Thomas Rosenberg
    • 2
  • A. Gal
    • 1
  1. 1.Institut für Humangenetik, Universitäts-Krankenhaus Eppendorf, Butenfeld 42, D-22529 Hamburg, Germany Tel.: +49-40-4717-2120, Fax: +49-40-4717-5138, e-mail: gal@plexus.uke.uni-hamburg.deDE
  2. 2.National Eye Clinic for the Visually Impaired, Hellerup, DenmarkDK