Original investigation

Human Genetics

, Volume 102, Issue 2, pp 138-140

Inheritance of chronic tension-type headache investigated by complex segregation analysis

  • Michael Bjørn RussellAffiliated withDepartment of Neurology, Glostrup Hospital, University of Copenhagen, DK-2600 Glostrup, Copenhagen, Denmark Fax: +45-43-23-39-26
  • , Lennart IseliusAffiliated withDepartment of Surgery, Karolinska Hospital, Stockholm, Sweden
  • , Steen ØstergaardAffiliated withDepartment of Neurology, Glostrup Hospital, University of Copenhagen, DK-2600 Glostrup, Copenhagen, Denmark Fax: +45-43-23-39-26
  • , Jes OlesenAffiliated withDepartment of Neurology, Glostrup Hospital, University of Copenhagen, DK-2600 Glostrup, Copenhagen, Denmark Fax: +45-43-23-39-26

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

We investigated the mode of inheritance of chronic tension-type headache in 122 families. The probands were from the Copenhagen Headache Clinic, Denmark. The criteria of the International Headache Society were used. The patterns of segregation of chronic tension-type headache were assessed by complex segregation analysis performed with the computer program POINTER. Of the 122 probands with chronic tension-type headache, 56 had 71 first-degree relatives with chronic tension-type headache. The complex segregation analysis indicates that chronic tension-type headache has multifactorial inheritance.