Human Genetics

, Volume 100, Issue 5, pp 611–619

The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13

Authors

  • Darek Kedra
    • Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden Tel.: +46-8-5177-2229; Fax: +46-8-5177-3909; e-mail: Jan.Dumanski@cmm.ki.se
  • Eyal Seroussi
    • Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden Tel.: +46-8-5177-2229; Fax: +46-8-5177-3909; e-mail: Jan.Dumanski@cmm.ki.se
  • Ingegerd Fransson
    • Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden Tel.: +46-8-5177-2229; Fax: +46-8-5177-3909; e-mail: Jan.Dumanski@cmm.ki.se
  • Jasmina Trifunovic
    • Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden Tel.: +46-8-5177-2229; Fax: +46-8-5177-3909; e-mail: Jan.Dumanski@cmm.ki.se
  • Melody Clark
    • MRC-HGMP Resource Centre, Hinxton, Cambridge, CB10 2SB, UK
  • Jacob Lagercrantz
    • Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden Tel.: +46-8-5177-2229; Fax: +46-8-5177-3909; e-mail: Jan.Dumanski@cmm.ki.se
  • Elisabeth Blennow
    • Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden Tel.: +46-8-5177-2229; Fax: +46-8-5177-3909; e-mail: Jan.Dumanski@cmm.ki.se
  • Hans Mehlin
    • Department of Cell and Molecular Biology, Karolinska Institutet, S-171 77 Stockholm, Sweden
  • J. Dumanski
    • Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden Tel.: +46-8-5177-2229; Fax: +46-8-5177-3909; e-mail: Jan.Dumanski@cmm.ki.se
Original investigation

DOI: 10.1007/s004390050562

Cite this article as:
Kedra, D., Seroussi, E., Fransson, I. et al. Hum Genet (1997) 100: 611. doi:10.1007/s004390050562

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is tightly linked to the muscle-type glycogen phosphorylase (PYGM) gene in 11q13. This region of the human genome contains additional disease-related loci implicated in the development of insulin-dependent diabetes mellitus, familial paraganglioma type 2, spinocerebellar ataxia type 5, Bardet-Biedl syndrome and translocation t(11;17) described in B-cell non-Hodgkin’s lymphoma. We approached cloning of candidate disease genes from 11q13 by large-scale genomic sequencing. We obtained > 106 kb of sequence around the PYGM gene and established a transcriptional map that includes: (i) two genes previously localized to 11q13, PYGM and a zinc-finger protein (ZFM1) gene; (ii) the germinal center kinase (GCK, human B-lymphocyte serine/threonine protein kinase) gene; (iii) a novel human CDC25-like (HCDC25L) gene; (iv) a dystrophia myotonica protein kinase-like (DMPKL) gene; and (v) a novel ubiquitously expressed gene of unknown function (germinal center kinase- neighboring gene, GCKNG).

Copyright information

© Springer-Verlag Berlin Heidelberg 1997