Human Genetics

, Volume 100, Issue 5, pp 611–619

The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13

  • Darek Kedra
  • Eyal Seroussi
  • Ingegerd Fransson
  • Jasmina Trifunovic
  • Melody Clark
  • Jacob Lagercrantz
  • Elisabeth Blennow
  • Hans Mehlin
  • J. Dumanski
Original investigation

DOI: 10.1007/s004390050562

Cite this article as:
Kedra, D., Seroussi, E., Fransson, I. et al. Hum Genet (1997) 100: 611. doi:10.1007/s004390050562

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is tightly linked to the muscle-type glycogen phosphorylase (PYGM) gene in 11q13. This region of the human genome contains additional disease-related loci implicated in the development of insulin-dependent diabetes mellitus, familial paraganglioma type 2, spinocerebellar ataxia type 5, Bardet-Biedl syndrome and translocation t(11;17) described in B-cell non-Hodgkin’s lymphoma. We approached cloning of candidate disease genes from 11q13 by large-scale genomic sequencing. We obtained > 106 kb of sequence around the PYGM gene and established a transcriptional map that includes: (i) two genes previously localized to 11q13, PYGM and a zinc-finger protein (ZFM1) gene; (ii) the germinal center kinase (GCK, human B-lymphocyte serine/threonine protein kinase) gene; (iii) a novel human CDC25-like (HCDC25L) gene; (iv) a dystrophia myotonica protein kinase-like (DMPKL) gene; and (v) a novel ubiquitously expressed gene of unknown function (germinal center kinase- neighboring gene, GCKNG).

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Darek Kedra
    • 1
  • Eyal Seroussi
    • 1
  • Ingegerd Fransson
    • 1
  • Jasmina Trifunovic
    • 1
  • Melody Clark
    • 2
  • Jacob Lagercrantz
    • 1
  • Elisabeth Blennow
    • 1
  • Hans Mehlin
    • 3
  • J. Dumanski
    • 1
  1. 1.Department of Molecular Medicine, Karolinska Hospital, CMM-building L8:00, S-171 76 Stockholm, Sweden Tel.: +46-8-5177-2229; Fax: +46-8-5177-3909; e-mail: Jan.Dumanski@cmm.ki.seSE
  2. 2.MRC-HGMP Resource Centre, Hinxton, Cambridge, CB10 2SB, UKGB
  3. 3.Department of Cell and Molecular Biology, Karolinska Institutet, S-171 77 Stockholm, SwedenSE