Human Genetics

, Volume 99, Issue 3, pp 295–297

The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p

Authors

  • Jaakko Kaukonen
    • Department of Clinical Medicine, University of Helsinki and the Laboratory Department of the Helsinki University Central Hospital, Haarmaninkatu 4, FIN-00290 Helsinki, Finland
  • Leena Alanen-Kurki
    • Turku Center for Biotechnology, Tykistokatu 6, BioCity, P.O. Box 123, FIN-20520 Turku, Finland
  • Markku Jalkanen
    • Turku Center for Biotechnology, Tykistokatu 6, BioCity, P.O. Box 123, FIN-20520 Turku, Finland
  • A. Palotie
    • Department of Clinical Medicine, University of Helsinki and the Laboratory Department of the Helsinki University Central Hospital, Haarmaninkatu 4, FIN-00290 Helsinki, Finland
Original investigation

DOI: 10.1007/s004390050360

Cite this article as:
Kaukonen, J., Alanen-Kurki, L., Jalkanen, M. et al. Hum Genet (1997) 99: 295. doi:10.1007/s004390050360

Abstract

The chromosomal locations of the human and mouse syndecan genes have been shown to associate with the corresponding locations of members of the myc gene family, proto-oncogenes that code for transcription factors. Here, we demonstrate the precise localization and order of the human syndecan-1 and N-myc genes using fluorescence in situ hybridization techniques that provide different levels of resolution. By visualizing the actual centromere-telomere orientation of these two genes, the human syndecan-1 gene is localized to 2p23–24, just centromeric to the N-myc gene at 2p24.1.

Copyright information

© Springer-Verlag Berlin Heidelberg 1997